What is the reference range for Ngal?

Introduction to NGAL and its Clinical Importance

Neutrophil Gelatinase-Associated Lipocalin (NGAL) is a biomarker that has gained considerable attention in the medical community for its role in diagnosing acute kidney injury (AKI). As an early indicator of renal stress, NGAL helps healthcare professionals in making timely and informed decisions about patient care. The NGAL test kit is a crucial tool that enables the accurate measurement of NGAL levels in patient samples, facilitating a more precise assessment of kidney function. Wholesale NGAL test kits are available from various manufacturers and suppliers, including NGAL test kit manufacturers and factories, which ensure that these vital diagnostic tools are readily accessible to laboratories worldwide.

Understanding the Reference Range for NGAL

The reference range for NGAL is pivotal in determining the risk and presence of acute kidney injury. It is through the careful analysis of these values that clinicians can categorize patients into different risk levels. The NGAL reference range is as follows: less than 50 ng/mL indicates a low risk of AKI, 50-149 ng/mL suggests an equivocal risk, 150-300 ng/mL denotes a moderate risk, and levels greater than 300 ng/mL are associated with a high risk of AKI. Understanding these ranges is essential for healthcare providers to make accurate diagnoses and develop effective treatment plans. The availability of wholesale NGAL test kits from various suppliers ensures that this critical diagnostic tool is available to those who need it.

Collection and Handling of Urine Samples for NGAL Testing

Proper collection and handling of urine samples are paramount to ensuring accurate NGAL test results. The preferred specimen type for NGAL testing is random urine, collected in a sterile container to prevent contamination. The NGAL test kit supplier provides detailed collection instructions, emphasizing the need for secure and upright storage of samples to maintain integrity. Additionally, sample volume is also crucial, with a minimum requirement of 2 mL to produce reliable results. These protocols are essential for labs and clinics that utilize NGAL test kits for diagnostic purposes, and the availability of wholesale NGAL test kits helps standardize these practices across various healthcare settings.

Laboratory Processing and Stability of NGAL Samples

Once collected, NGAL samples require specific processing and storage conditions to ensure validity. The processing involves centrifuging the sample to separate the components, without the need for aliquoting. The transport temperature is critical, as samples should be refrigerated and are stable for up to 48 hours at 2-8°C. If longer storage is required, freezing at -20°C or below is recommended. These guidelines ensure that the NGAL test kit delivers accurate and consistent results, a crucial factor for test kit manufacturers and factories to consider. The stability of these samples is vital for labs that rely on NGAL testing in diagnosing renal injuries.

Interpreting NGAL Test Results for Acute Kidney Injury

Interpreting NGAL test results accurately is essential for assessing the risk of acute kidney injury. Results below 50 ng/mL suggest a low risk, but clinicians are advised to continue monitoring, especially if clinical symptoms persist. Levels between 50-149 ng/mL are equivocal, calling for a repeat measurement to confirm risk. Moderate risk, indicated by 150-300 ng/mL, requires careful patient assessment and potentially more aggressive intervention. High levels, over 300 ng/mL, indicate a significant risk of AKI with high specificity. Wholesale NGAL test kits, sourced from reputable manufacturers and suppliers, are essential for facilitating this critical interpretation process in clinical settings.

Clinical Implications of Low NGAL Levels

Low NGAL levels, while generally indicative of a minimal risk of acute kidney injury, do not entirely exclude the potential for renal issues in the future. It is crucial for clinicians to remain vigilant and consider the broader clinical context and any other symptoms the patient may be experiencing. Regular monitoring and reassessment are recommended, especially if there are changes in the patient's condition. NGAL test kit manufacturers and suppliers provide tools that help healthcare providers track these levels efficiently, enhancing patient care and outcomes.

Significance of Equivocal NGAL Levels in Diagnosis

When NGAL levels fall within the equivocal range of 50-149 ng/mL, it poses a challenge for clinicians in terms of diagnosis and management. This range suggests an uncertain risk of AKI, necessitating a repeat test to ascertain the patient's status. The ambiguity inherent in this range requires a careful evaluation of the patient's clinical presentation and history. The use of NGAL test kits, available from various suppliers and manufacturers, becomes crucial at this stage, enabling healthcare providers to make informed decisions regarding potential interventions and monitoring strategies.

Moderate Risk Indications and Clinical Actions for NGAL

Patients with NGAL levels of 150-300 ng/mL are considered at moderate risk for acute kidney injury. This categorization demands a proactive approach from healthcare providers, with a focus on identifying and mitigating potential contributing factors to kidney damage. Interventions may include adjusting medications, ensuring adequate hydration, and close monitoring of renal function. The role of NGAL test kits is vital in this context, providing reliable data that aids in tailoring patient-specific management plans. Wholesale NGAL test kits from reputable suppliers support healthcare facilities in implementing these necessary clinical actions.

High NGAL Levels and Predictive Value for Kidney Injury

High NGAL levels, exceeding 300 ng/mL, are strongly indicative of a high risk for acute kidney injury, offering substantial predictive value due to the test's high specificity. Patients within this category require immediate and intensive evaluation and management to prevent progression of renal damage. The availability of NGAL test kits from trusted manufacturers and suppliers plays a critical role in this process, ensuring that healthcare providers have access to accurate and reliable diagnostic tools necessary for prompt decision-making.

Regulatory and Methodological Aspects of NGAL Testing

The NGAL test operates under stringent regulatory frameworks and methodologies to ensure its efficacy and reliability. Laboratories conducting these tests must comply with guidelines set forth by CLIA, CAP, and other relevant regulatory bodies. The NGAL test kit supplier ensures that the kits adhere to these standards, providing confidence in the results produced. Additionally, the methodology, often involving Particle Enhanced Turbimetric Immunoassays, is designed to deliver highly sensitive and specific results. Wholesale NGAL test kits are distributed by suppliers who are keenly aware of these regulatory requirements, ensuring that labs worldwide maintain the highest standards of testing.

Clongene Biotech: A Trusted NGAL Test Kit Manufacturer

Hangzhou Clongene Biotech Co., Ltd., established in 2004, is a leading national high-tech enterprise specializing in Biological Raw Materials, Diagnostic Reagents, and CRO/CDMO Services. With two decades of expertise in the diagnostic industry, Clongene is dedicated to delivering high-quality products and professional technical services to its clientele. The company excels in the development of antigens, antibodies, and molecular diagnostic enzymes across various medical fields, including infectious diseases and tumor markers. Clongene's commitment to innovation has earned it a reputation for reliability and excellence, with its products reaching over 100 countries worldwide, backed by authoritative certifications such as NMPA, FDA, and CE.